Intracellular inhibitors of innate immunity from Vaccinia virus
نویسنده
چکیده
s 160th Meeting 26–29 March 2007 University of Manchester Intracellular life of microbes Plenary session 3 Microbial transport systems Cells & Cell Surfaces Group session 7 Bacterial colonization, latency and host adaptation Microbial Infection Group / Clinical Microbiology Group joint session 9 Blood-borne virus infections Clinical Virology Group session 13 Training of medical and dental students – making microbiology more relevant Education & Training Group / Clinical Microbiology Group / Clinical Virology Group joint session 15 Soil microbiology: revisiting the past and developing the future Environmental Microbiology Group with the British Society for Soil Science and the British Mycological Society joint session 17 Protein expression strategies: a comparative view Fermentation & Bioprocessing Group session 20 Mechanisms of survival of Gram-positive pathogens during food processing Food & Beverages Group session 22 Systems biology of regulatory networks Physiology, Biochemistry & Molecular Genetics Group session 24 Alphaproteobacteria: unifying a diverse class Systematics & Evolution Group session 27 Molecular aspects of virus replication from entry through to exit Virus Group session 30 Fleming Prize Lecture Gregory L. Challis (University of Warwick) Mining microbial genomes for new natural products and biosynthetic pathways 35 Colworth Prize Lecture Paul Williams (University of Nottingham) Look who’s talking: communication and co-operation in the bacterial world 35
منابع مشابه
A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB.
The classical nuclear factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immunity that is activated by a wide variety of stimuli, including virus infection, tumor necrosis factor alpha (TNF-α), and interleukin 1β (IL-1β). Poxviruses, including vaccinia virus (VV) and ectromelia virus, encode multiple proteins that function in immune evasion. Recently, ...
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Vaccinia virus (VACV) is the prototypic orthopoxvirus and the vaccine used to eradicate smallpox. Here we show that VACV strain Western Reserve protein 169 is a cytoplasmic polypeptide expressed early during infection that is excluded from virus factories and inhibits the initiation of cap-dependent and cap-independent translation. Ectopic expression of protein 169 causes the accumulation of 80...
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In oncolytic virotherapy, the ability of the virus to activate the immune system is a key attribute with regard to long-term antitumor effects. Vaccinia viruses bear one of the strongest oncolytic activities among all oncolytic viruses. However, its capacity for stimulation of antitumor immunity is not optimal, mainly due to its immunosuppressive nature. To overcome this problem, we developed a...
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